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Advocate™ Ultra Chew FAQs

Explore our frequently asked questions about Advocate Ultra Chew for Dogs

Advocate Ultra Chew FAQs 

Basic Product Information

Usage & Application

Effectiveness & Results

Safety & Precautions

Specific Parasites and Concerns

Specific Parasites and Concerns

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Troubleshooting

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*Of all canine ‘all-in-ones’ (products that protect against fleas, ticks, heartworm & intestinal worms), based on number of parasites controlled.

~Ixodes ricinus

  1. Elanco data on file.
  2. Cavalleri, D. et al. (2017). Assessment of the onset of lotilaner (CredelioTM) speed of kill of fleas on dogs. Parasit Vectors. 10(1):521.
  3. Cavalleri, D. et al. (2017). Assessment of the speed of flea kill of lotilaner (CredelioTM) throughout the month following oral administration to dogs. Parasit Vectors. 10(1):529.
  4. Murphy, M. et al. (2017). Laboratory evaluation of the speed of kill of lotilaner (CredelioTM) against Ixodes ricinus ticks on dogs. Parasit Vectors. 10(1):541.
  5. Reif, K. et al. (2024). Comparative speed of kill provided by lotilaner (CredelioTM), sarolaner (Simparica TrioTM), and afoxolaner (Nexgard SpectraTM) to control Amblyomma americanum infestations on dogs. Parasit Vectors. 17(1):313.
  6. Lyons, R. et al. (2025, November 6-7), Speed-of-kill comparison of isoxazolines in the combination endectocide products CredelioTM PLUS (lotilaner), Nexgard® Spectra (afoxolaner) and Simparica® Trio (sarolaner) against the Australian paralysis tick (Ixodes holocyclus) throughout one month. [Poster session]. 1st Asia Pacific Veterinary Parasitology Congress (APAVP), Kuala Lumpur, Malaysia
  7. Riggs. K. et al. (2025). Safety of Credelio QuattroTM (lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets) in homozygous MDR1-mutant collie dogs. Parasit Vectors. 2025 Apr 23;18(1):153.

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