Advocate™ Ultra Chew FAQs
Explore our frequently asked questions about Advocate Ultra Chew for Dogs
Advocate Ultra Chew FAQs
Basic Product Information
Advocate Ultra Chew is the broadest spectrum parasiticide*. Advocate Ultra Chew is a monthly all-in-one chew that protects dogs against ticks, fleas, heartworm disease, tapeworms, roundworms, hookworms and demodex mites.
Advocate Ultra Chew protects against ticks, fleas, heartworm disease, tapeworms, roundworms, hookworms and demodex mites.
Advocate Ultra Chew contains four active ingredients - lotilaner, praziquantel, pyrantel and moxidectin.
In Australia, Advocate Ultra Chew is available without a prescription from your vet and select pet supply retailers. See where you can buy Advocate Ultra Chew here.
Advocate Ultra Chew is beef flavoured, but the flavouring is vegetable-based. This means that it is meat allergen free1 and suitable for dogs on restricted diets.
Usage & Application
Many dogs will readily eat Advocate Ultra Chew due to its smell and taste. If your dog is hesitant, you can wrap it in a small piece of food e.g. meat or cheese. Advocate Ultra Chew should always be given with or following food. This is important for optimal absorption of the active ingredients. Ensure your dog consumes the entire tablet. If the entire dose is not consumed, re-administer as soon as possible with the full dose.
Advocate Ultra Chew should be administered on a monthly basis, preferably on the same date each month.
Advocate Ultra Chew comes in five tablet strengths, so you can get the ideal dose for your dog based on their weight. Weight ranges are:
- 2.0 – 2.8 kg
- 2.9 – 5.5 kg
- 5.6 – 11 kg
- 11.1 – 22 kg
- 22.1 – 45 kg
For dogs over 45 kg, administer the appropriate combination of tablets.
Our Animal Health Consultants can answer any questions you may have about the suitable dose for your dog. The team can be contacted on 1800 995 709 or productsupportau@elancoah.com.
Advocate Ultra Chew is labelled to be administered once monthly. Using Advocate Ultra Chew less frequently than once a month could result in a decrease in expected efficacy.
If you have missed a dose, please administer the appropriate dose with food as soon as possible and resume a monthly dosing schedule.
If your dog spits out or refuses to eat Advocate Ultra Chew, try re-offering it with a small amount of their favourite treat, such as cheese or dog-safe peanut butter, to encourage them. Ensure your dog eats the entire chew. If the entire chew is not consumed, re-administer as soon as possible with the full dose. Always give Advocate Ultra Chew with or following food.
Advocate Ultra Chew is safe to use as directed for puppies from 2 kg and 8 weeks of age. See product label for full claim details and directions for use.
Yes, Advocate Ultra Chew should be given with food or within 30 minutes of feeding.
Advocate Ultra Chew should be stored below 30⁰C (room temperature). For those in warmer areas of Australia, call our Animal Health Consultants on 1800 995 709 for further advice.
As Advocate Ultra Chew is an oral product, there are no restrictions with regards to swimming or washing after treatment. Your dog can be treated while they are wet and can be exposed to water immediately after treatment.
Effectiveness & Results
Advocate Ultra Chew offers the fastest speed of kill against ticks and fleas*2-6. The active ingredient in Advocate Ultra Chew, lotilaner, is rapidly absorbed into the bloodstream and starts killing fleas within 2 hours2, and starts killing ticks within 4 hours~4.
No tick product is 100% effective. Therefore, in tick season, daily searching for, and removal of, any ticks found is recommended.
Yes, Advocate Ultra Chew will kill fleas present on your dog at the time of application and kill reinfesting fleas for one month.
Safety & Precautions
Advocate Ultra Chew is safe for dogs and puppies from 2.0 kg and 8 weeks of age when used as per the product label. One of the active ingredients in Advocate Ultra Chew, lotilaner, is part of the isoxazoline family of chemicals. Adverse reactions to this family of chemicals are rarely observed, but may include vomiting, diarrhoea, lethargy, inappetence, itching and very rarely, seizures. Most adverse reactions are self-limiting and of short duration. Of these adverse events, vomiting and diarrhoea are the most common. If you have any concerns, please contact your veterinarian or speak to Elanco’s Animal Health Consultants on 1800 995 709.
Advocate Ultra Chew is safe for dogs and puppies from 2 kg and 8 weeks of age when used as per the product label. Additionally, Advocate Ultra Chew has been shown to be safe in heartworm-positive dogs, and in ivermectin-sensitive breeds including Collies7. Always ensure you select the correct chew size based on your dog's weight.
Advocate Ultra Chew should be used with caution in breeding, pregnant and lactating dogs, as safety has not been evaluated in these dogs. For parasite prevention for your breeding, pregnant or lactating dog, contact your veterinarian for advice.
If your dog consumes an overdose of Advocate Ultra Chew, contact your veterinarian.
No, Advocate Ultra Chew should not be administered to cats. For flea and tick prevention for cats, consider SerestoTM Collar for Cats. For intestinal worm and heartworm control, MilbemaxTM for Cats can be used. If you prefer a topical treatment for your cat, consider AdvocateTM Spot-On for Cats, which protects against fleas, heartworm, intestinal worms and lungworms.
Advocate Ultra Chew has shown to be safe in ivermectin-sensitive Collies7.
Specific Parasites and Concerns
Yes, Advocate Ultra Chew is safe to use in heartworm-positive dogs. However, it is recommended that all animals over the age of 6 months of age be tested for existing heartworm infections before beginning medication with Advocate Ultra Chew.
Advocate Ultra Chew kills adult fleas on your dog rapidly, preventing further environmental contamination with flea eggs. Advocate Ultra Chew will not kill flea eggs, larvae or pupae that are already in your dog's environment. These environmental flea stages will need to mature into adult fleas, jump onto your Advocate Ultra Chew treated dog, to be quickly killed (within 4-6 hours). It can take weeks to months to resolve a flea infestation in a home. For more rapid resolution, effective environmental flea control may be required, alongside regular flea prevention for all pets in the household.
Yes, it is possible to contract flea tapeworm or hydatid tapeworm from your dog. Humans, mainly children, can become infected with the flea tapeworm if they accidentally consume an infected flea (e.g. after patting their flea-infested pet). Hydatid tapeworm can cause a serious condition in humans called hydatid disease. This disease can occur in humans who accidentally ingest hydatid tapeworm eggs from the environment. These eggs can migrate from the intestinal tract and lodge in various organs (mainly the liver, lungs and brain), where they grow into large cyst-like structures, resulting in serious and potentially life-threatening diseases. Hydatid disease is difficult to treat and control, so reducing the likelihood of exposure by regularly deworming your dog, preventing your dog from scavenging and maintaining good hygiene practices is very important.
Advocate Ultra Chew treats and controls tapeworms in dogs, including the potentially deadly hydatid tapeworm.
Yes, it is possible for humans to contract certain types of worms from dogs through what is known as zoonotic transmission. Roundworm eggs are passed in a dog's stool and can survive in the soil for long periods, meaning that you can accidentally ingest them when touching contaminated dirt or dog's fur and then touching your mouth.
Hookworm larvae can burrow directly into the skin if you happen to walk barefoot through an area where an infected dog has been.
Tapeworms can also infect people. Humans, mainly children, can become infected with the flea tapeworm if they accidentally consume an infected flea (e.g. after patting their flea-infested pet). Hydatid tapeworm eggs can also be accidentally ingested from the environment. Hydatid disease is a serious condition that is difficult to treat and control, so reducing the likelihood of exposure by regularly deworming your dog, preventing your dog from scavenging and maintaining good hygiene practices is very important. Learn more about the transmission of worms between dogs and humans here.
Tapeworm infections in dogs are easy to miss but can be a serious risk to people. Most dogs with tapeworm infections don't look sick at all, which is why infections often go unnoticed. However, some types like Echinococcus granulosus can be passed from dogs to humans and may cause potentially fatal cysts in human organs. Advocate Ultra Chew is the only all-in-one chew that kills tapeworms too.
Dogs primarily get flea tapeworms by infected fleas while grooming. Fleas act as intermediate hosts, carrying flea tapeworm larvae that mature in the dog's intestines.
Dogs can get hydatid tapeworm by eating raw or undercooked meat or offal from infected animals. This can include livestock (such as sheep) or wildlife (such as kangaroos, wallabies or rodents).
Yes, Advocate Ultra Chew protects dogs against paralysis ticks, brown dog ticks, and bush ticks. No tick product is 100% effective, therefore, in tick season, daily searching for, and removal of, any ticks found is recommended.
No, Advocate Ultra Chew won’t protect your dog against ehrlichiosis. For ehrlichiosis protection, apply a SerestoTM Collar for Dogs. Advocate Ultra Chew can be safely used alongside Seresto, and this is recommended for dogs at high risk of ehrlichiosis.
Yes, Advocate Ultra Chew prevents heartworm disease when administered on a regularly monthly basis.
Yes, Advocate Ultra Chew protects your dog against roundworms, hookworms and tapeworms.
Yes, Advocate Ultra Chew protects dogs against fleas.
Specific Parasites and Concerns
Choosing between Advocate Ultra Chew and Advocate Spot-On depends on the level of protection your dog needs and your preferred way to treat them. Advocate Ultra Chew is our newest innovation for dogs, offering the broadest parasite protection in a single monthly dose*. Advocate Ultra Chew contains lotilaner, moxidectin, pyrantel and praziquantel to protect against fleas, heartworm, intestinal worms and demodex mites while also adding coverage for ticks and tapeworms. This makes it a convenient all-in-one solution for dog owners who want piece of mind without needing to use multiple different products.
On the other hand, Advocate Spot-On is a trusted topical treatment applied directly to the skin, and can be used on both cats and dogs. Advocate Spot-On uses two active ingredients - imidacloprid and moxidectin. It kills fleas on contact, which means they do not have to bite your pet to die. Advocate Spot-On provides monthly protection against fleas, heartworm, intestinal worms and demodex mites, but it does not cover ticks or tapeworms. Advocate Spot-On remains a great choice for pets that do not require tick or tapeworm protection, or prefer a topical application over an oral chew.
Before changing to Advocate Ultra Chew, check that your dog is older than 8 weeks of age, and weighs at least 2 kg. If changing from a product that provides tick control, maintain the dosing interval of the original product - i.e. start Advocate Ultra Chew when your dog is next due for their tick prevention treatment, then continue monthly dosing. However, if changing from a product that does not control ticks, it is important to start protecting your dog as soon as possible. Give Advocate Ultra Chew with your dog's next meal. However, if you've given your dog a worming product today, wait a couple of days before administering Advocate Ultra Chew. For further advice, contact our Animal Health Consultants on 1800 995 709.
Yes, Advocate Ultra Chew can be used with Seresto Collar for Dogs for additional and complementary tick protection. Seresto is recommended for all dogs at risk of ehrlichiosis, as it is the only product that reduces the transmission of this deadly disease transmitted between dogs by brown dog ticks. Seresto also repels and kills paralysis ticks, making it a great addition for dogs in high tick areas. For further advice, talk to your vet.
In Australia, Credelio Quattro is sold under the brand name Advocate Ultra Chew.
Purchasing
Advocate Ultra Chew can be purchased from veterinary clinics and pet supply stores. See where you can buy Advocate Ultra Chew here.
Troubleshooting
It is possible to observe fleas on your dog even after administering Advocate Ultra Chew. Adult fleas must come into contact with your dog and bite to be killed by Advocate Ultra Chew. Fleas already on your dog will start to die within 2 hours and be killed within 4-6 hours of treating your dog with Advocate Ultra Chew. New fleas that jump onto your dog throughout the month will be rapidly killed, within 4-6 hours. Fleas can be difficult to control, because the majority of the flea population in the home is in the form of flea eggs, larvae and pupae, rather than adult fleas on the dog. For this reason, it can take several weeks to months to eliminate a flea infestation in the home. Regular flea treatment of all pets in the household is important, and environmental control measures are also recommended in cases of heavy infestation.
If you have concerns about persistent infestations, contact our Animal Health Consultants on 1800 995 709 for guidance.
If your dog vomits after receiving Advocate Ultra Chew, contact our Animal Health Consultants on 1800 995 709 or speak to your veterinarian for advice.
In tick season, daily searching for, and removal of, any ticks found is recommended. If you find a tick on your dog:
- Remove the tick immediately. Advocate Ultra Chew kills ticks when they attach and feed, so it is possible to find dead or dying ticks, or even live ticks that have not yet ingested a lethal dose.
- Monitor your dog for signs of tick paralysis or tick-borne disease. Contact your veterinarian if your dog experiences vomiting, lethargy, changes in bark, difficulty walking, fever, inappetence, abnormal bruising or bleeding or any other signs of illness.
If you find a tick on your dog after they have been administered Advocate Ultra Chew, contact our Animal Health Consultants on 1800 995 709.
If your dog is under 2 kg, consider a different flea and tick preventative product, such as Seresto Collar for Dogs, which can be used in puppies from 7 weeks of age and any weight.
If your dog is over 45 kg, administer the appropriate combination of Advocate Ultra Chew. For example, for a 60 kg dog, administer two Advocate Ultra Chews for Dogs 22-45 kg.
If you have further questions about the correct dose for your dog, contact our Animal Health Consultants on 1800 995 709.
Want to learn more about Advocate Ultra Chew?
*Of all canine ‘all-in-ones’ (products that protect against fleas, ticks, heartworm & intestinal worms), based on number of parasites controlled.
~Ixodes ricinus
- Elanco data on file.
- Cavalleri, D. et al. (2017). Assessment of the onset of lotilaner (CredelioTM) speed of kill of fleas on dogs. Parasit Vectors. 10(1):521.
- Cavalleri, D. et al. (2017). Assessment of the speed of flea kill of lotilaner (CredelioTM) throughout the month following oral administration to dogs. Parasit Vectors. 10(1):529.
- Murphy, M. et al. (2017). Laboratory evaluation of the speed of kill of lotilaner (CredelioTM) against Ixodes ricinus ticks on dogs. Parasit Vectors. 10(1):541.
- Reif, K. et al. (2024). Comparative speed of kill provided by lotilaner (CredelioTM), sarolaner (Simparica TrioTM), and afoxolaner (Nexgard SpectraTM) to control Amblyomma americanum infestations on dogs. Parasit Vectors. 17(1):313.
- Lyons, R. et al. (2025, November 6-7), Speed-of-kill comparison of isoxazolines in the combination endectocide products CredelioTM PLUS (lotilaner), Nexgard® Spectra (afoxolaner) and Simparica® Trio (sarolaner) against the Australian paralysis tick (Ixodes holocyclus) throughout one month. [Poster session]. 1st Asia Pacific Veterinary Parasitology Congress (APAVP), Kuala Lumpur, Malaysia
- Riggs. K. et al. (2025). Safety of Credelio QuattroTM (lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets) in homozygous MDR1-mutant collie dogs. Parasit Vectors. 2025 Apr 23;18(1):153.